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Penicillin cocktail

Difford’s Guide
Discerning Drinkers (564)
Measurements in:
Serves:
1
Ingredients
1 12 fl oz Blended Scotch whisky
12 fl oz Ginger liqueur
13 fl oz Peated single malt whisky
23 fl oz Lemon juice (freshly squeezed)
23 fl oz Honey syrup (3 parts honey to 1 water by weight)

How to make

Glass

Photographed in an UB Koto Old Fashioned 30cl

Prepare

  1. Select and pre-chill an OLD-FASHIONED GLASS.
  2. Prepare skewered crystallised ginger for garnish.

Method

  1. SHAKE all ingredients with ice.
  2. STRAIN into ice-filled glass (preferably over a large cube or chunk of block ice).

Garnish

  1. Garnish with skewered crystallised ginger.

Flavour Profile

No alcohol
Medium
Boozy
Sweet
Medium
Dry/sour

Health & Nutrition

Nutrition:

One serving of Penicillin cocktail contains 220 calories

Alcohol content:

  • 1.5 standard drinks
  • 17.41% alc./vol. (34.83° proof)
  • 20.6 grams of pure alcohol

History

Adapted from a 2005 recipe created by Sam Ross at Milk & Honey in Manhattan, New York City. Sam's original recipe (below) calls for ¾ oz honey-ginger syrup in place of ginger liqueur and honey.

Sam Ross's Penicillin recipe
Glass: Old-fashioned
Garnish: Skewered crystallised ginger
Method: SHAKE first 3 ingredients with ice and strain into ice-filled glass. TOP with Islay whisky.
60ml (2oz) Blended Scotch whisky
22.5ml (¾oz) Lemon juice (freshly squeezed)
22.5ml (¾oz) Honey & ginger syrup*
7.5ml (¼oz) Peated Islay single malt scotch whisky

*To make honey & ginger syrup
Peel and thinly slice 100 grams (3.5oz) of root ginger and place in a saucepan with 1 cup of honey and 1 cup of water. Bring to a boil, then reduce heat and simmer for 5 minutes. Allow to cool and place in a sealed container in a refrigerator to steep for 12 hours. Strain, bottle, and store in a refrigerator. Use within three days.

I created my version of Sam's contemporary classic, using ginger liqueur to avoid the faff of making ginger honey syrup, back in March 2009. With a good liqueur, it retains much of the ginger spice but in a more mellow form than the heat of fresh ginger juice. However, in February 2025, I came across a clutch of excellent cocktails (led by the Toreador del Diablo) made with ginger juice syrup. As to hand, I used this to create another version of the Penicillin:

Difford's Ginger Juice Syrup Penicillin
Glass: Old-fashioned
Garnish: Skewered crystallised ginger
Method: SHAKE all ingredients with ice and strain into ice-filled glass.
45ml (1½oz) Blended Scotch whisky
10ml (⅓oz) Peated single malt scotch whisky
7.5ml (¼oz) Ginger juice syrup
15ml (½oz) Honey syrup (3 honey to 1 water)
20ml (⅔oz) Lemon juice (freshly squeezed)

Review

A Whisky Sour with honey richness, subtle smoke and enlivening ginger spice. A cocktail to slap the palate awake. Then you can't resist keep sipping it.

Cocktail of the day:

7th April 2026 is World Health Day

Variations/similar cocktails

The Penicillin cocktail originated as a riff on a Gold Rush

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$3.47 per cocktail*

Makes a minimum of 16.5 cocktails.
Shipping and applicable tax calculated at checkout.


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Gallery

Comments & Discussion

Graeme McPherson
I’ve been waiting for a long time to make this cocktail but had to wait until I could justify having all the separate ingredients in the house at the same time. Finally got a chance to make one last night and I could instantly taste why this one gets so much hype as a modern classic. As the kids would say this one is a banger! Made mine with Monkey Shoulder and Ardbeg Wee Beastie for the peat. A sublime sipper.
score: 3
Caspian Berggren Premium Member
Once when I was a wee lad, early in my cocktail journey, I made this with simple syrup because I thought "what difference can honey do?" and I thought the drink was kind of meh. Didn’t make it again for quite a while because in my mind it was always a mediocre cocktail. Fast forward a couple of years and I can now see the errors of my way. The smooth honey is what keeps it all together!
score: 1
OodelallyGolly
I made this with Rubenesque Bourbon for the scotch and Bullit Rye for the peated whisky. I thought this was a lovely drink. Next time, maybe I'll try a different ginger liquor (I used Mr. Stacks, but it was a budget choice and not a quality one), and it might add more "umph".
score: 1
Mookie Premium Member
This really is a perfect drink. I opted to shake the peated scotch in with the rest of the drink, but used an atomizer to garnish with a few spritzes of additional smokey goodness.
score: 5
Simon Sedgley Premium Member
Our only 'improvement' was to add some Fee Foam for a cheerful head. After all, happily taking one's medicine need not be a contradiction in terms.
score: 2
Olga K
My love at first sip. And a love that lasts a long time, which is rare for me.
score: 2
Patricio González-Careaga López-Tapia Premium Member
Is it Ginger Liqueur, or Ginger Syrup?
score: 2
Simon Difford Verified User Premium Member
There are recipes with both above. The main (top of the page) recipe uses liqueur.
score: 1
Justin Aniello
Half the lemon and slightly heavier on the ginger made it more to my liking, though I generally reduce any lemon in a recipe
score: 3
Charlie Forbes Premium Member
Lots of different ways to get to this destination (or nearby): also fun to make w/ ginger juice for an extra kick, or with just honey (who has time for ginger syrup - honestly), with ginger preserves and half the honey for the same idea. You can also mule this thing up by lengthening w/ ginger beer for a long, spicy, summer refresher.
score: 2
Dan Hunter Premium Member
The spicy summer refresher is lights out my man. Good show.
score: 2
Matt Premium Member
A great way to enjoy a smoky scotch whisky, and to intoduce friends to the potential. I used ginger syrup instead of honey. I don't get distinct flavors of lemon and ginger, instead I get some brightness and lightness from the citrus, and some spicy bite from the ginger - very nice to lighten and enliven the smoky weight (even though diluted with blended scotch) of the Islay scotch (that's what I use).
score: 0

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Difford’s Shop logo
$3.47 per cocktail*

Makes a minimum of 16.5 cocktails.
Shipping and applicable tax calculated at checkout.


Orders are processed by a licensed Fulproof retailer. The buy now button is added simply for convenience.

Checkout

* May not include all ingredients. Price per cocktail is an estimate based on cost of one cocktail with ingredients shown above and does not include shipping.